Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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2,086 – 2,100 of 3,758 results

2,086

Ambeed 3Chloro5nitrobenzoic acid

3-Chloro-5-nitrobenzoic acid, 34662-36-7, 98%

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2,087

Ambeed Benzyl 3oxocyclobutyl carbama

Benzyl (3-oxocyclobutyl)carbamate, 130369-36-7, 97%

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2,088

Ambeed 11bR 2R 5R 1 Dinaphtho 2 1d

(11bR)-(2R,5R)-1-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2,5-diphenylpyrrolidine, 444667-33-8, 98%

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2,089

Ambeed 3 4Chlorophenyl N pyridin4ylme

3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide, 915385-81-8, 98%

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2,090

Ambeed 11bR 2R 5R 1 Dinaphtho 2 1d

(11bR)-(2R,5R)-1-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2,5-diphenylpyrrolidine, 444667-33-8, 98%

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2,091

Ambeed Palladium II acetate

Palladium(II) acetate, 3375-31-3, 99.9%

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2,092

Ambeed 11bR 2R 5R 1 Dinaphtho 2 1d

(11bR)-(2R,5R)-1-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-2,5-diphenylpyrrolidine, 444667-33-8, 98%

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2,093

Ambeed Dicyclohexyl 3isopropoxy2 4

Dicyclohexyl(3-isopropoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine, 2118959-55-8, 97%

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2,094

Ambeed 7Bromo3 4dihydroquinolin2 1H o

7-Bromo-3,4-dihydroquinolin-2(1H)-one, 14548-51-7, 97%

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2,095

Ambeed 5Amino2methoxypyrimidine

5-Amino-2-methoxypyrimidine, 56621-89-7, 98%

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2,096

Apexbio Technology LLC MK-5108 (VX-689) 1010085-13-8 200mg

MK-5108 (VX-689 CAS 1010085-13-8) is a selective inhibitor targeting Aurora A kinase (AAK) functioning through competitive interaction with its ATP-binding pocket It exhibits sub-nanomolar inhibition of Aurora A kinase (IC50 0 064 nM) and displays additional inhibitory activity against Aurora B and Aurora C kinases (IC50 14 nM and IC50 12 nM respectively) MK-5108 has been extensively studied in cancer research contexts demonstrating antiproliferative activity across various tumor types including breast cervical colorectal ovarian and pancreatic cancers

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2,097

Apexbio Technology LLC KU-60019 925701-49-1 200mg

KU-60019 is a selective inhibitor targeting ataxia telangiectasia mutated (ATM) kinase with an IC50 value of approximately 6 3 nM Through inhibition of ATM kinase activity KU-60019 influences cellular DNA damage responses and sensitivity to radiation therapy It has been demonstrated to enhance radiosensitivity in human fibroblast cells expressing functional ATM but not in ATM-deficient cells Additionally KU-60019 reduces radiation-induced phosphorylation of AKT at Ser473 in glioma cell lines independently affecting cell migration invasion and proliferation KU-60019 serves as an investigational tool for exploring ATM-dependent signaling pathways and examining therapeutic strategies against cancers involving ATM-regulated DNA repair and cell survival mechanisms

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2,098

Apexbio Technology LLC Tideglusib 865854-05-3 200mg

Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity